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3X Genetics

NYU Langone Health
3X Genetics

FECD Study — Participant Data Entry

Genetic Testing of FECD Patients for DMPK and TCF4 CTG Repeat Expansions

For study staff. Complete one entry per enrolled participant using the participant’s Case Report Form (CRF) as the source. This is a cross-sectional, observational study — one visit, no follow-up. Enter clinical values exactly as recorded on the CRF. Do not enter names or MRN; this record is de-identified.

IRB: NYULH s25-01649
Collaborator: 3X Genetics

Participant Data Entry

Fields marked * are required. All other fields mirror the NYULH CRF (Modules 4–5); leave blank or use the CRF’s N/D convention where a value was not recorded.

Kit & Enrollment








Demographics











FECD Clinical Assessment & Family History








5a — Fuchs Grade (Modified Krachmer)

Mild = grade 1–2 (1 = 1–12 central guttae; 2 = >12 central non-confluent guttae). Moderate = grade 3–4 (3 = 1–2 mm confluent; 4 = 2–5 mm confluent). Severe = grade 5–6 (5 = >5 mm confluent; 6 = confluent with stromal/epithelial edema). Grade 0 is not an option (FECD is an enrollment criterion).







5b — Central Corneal Thickness (CCT)

Record three measurements per eye (µm). The average is calculated automatically. Leave an eye blank and its “Average” stays empty.

OD (right)

OS (left)



5c — Family History







© 2026 3X Genetics — NYULH IRB s25-01649. Study source data; handle per protocol. No direct identifiers.